Nutropin Depot

Nutropin Depot

£180.00

Nutropin Depot Description

Buy Nutropin Depot Online [somatropin (rDNA origin) for injectable suspension] is a long‑acting dosage form of recombinant human growth hormone (rhGH). Somatropin has 191 amino acid residues and a molecular weight of 22,125 daltons. The amino acid sequence of the product is identical to that of pituitary‑derived human growth hormone. The protein is synthesized by a specific laboratory strain of E. coli as a precursor consisting of the rhGH molecule preceded by the secretion signal from an E. coli protein. This precursor is directed to the plasma membrane of the cell. The signal sequence is removed and the native protein is secreted into the periplasm so that the protein is folded appropriately as it is synthesized.

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Description

Buy Nutropin Depot  Online

Buy Nutropin Depot Online [somatropin (rDNA origin) for injectable suspension] is a long-acting dosage form of recombinant human growth hormone (rhGH). Somatropin has 191 amino acid residues and a molecular weight of 22,125 daltons, Buy HGH Online. The amino acid sequence of the product is identical to that of pituitary-derived human growth hormone, Buy Steroid Online. The protein is synthesized by a specific laboratory strainof E, Buy Human Growth Hormones Online. coli as a precursor consisting of the rhGH molecule preceded by the secretion signal from an E, Buy Growth Hormones Online. coli protein. This precursor is directed to the plasma membrane of the cell, Buy Drugs Online. The signal sequence is removed and the native protein is secreted into the periplasm so that the protein is folded appropriately as it is synthesized.

Somatropin is a highly purified preparation. Biological potency is determined using a cell proliferation bioassay.

The Nutropin Depot (somatropin rdna origin for inj) formulation consists of micronized particles of rhGH embedded in biocompatible, biodegradable polylactide-coglycolide (PLG) microspheres. Nutropin Depot (somatropin rdna origin for inj) is packaged in vials as a sterile, white to off-white, preservative-free, free-flowing powder. Before administration, the powder is suspended in Diluent for Nutropin Depot (somatropin rdna origin for inj) (a sterile aqueous solution).

Each 13.5 mg 3 cc single-use vial of Nutropin Depot (somatropin rdna origin for inj) contains 13.5 mg somatropin, 1.2 mg zinc acetate, 0.8 mg zinc carbonate, and 68.9 mg PLG.

Each 18 mg 3 cc single-use vial of Nutropin Depot (somatropin rdna origin for inj) contains 18 mg somatropin, 1.6 mg zinc acetate, 1.1 mg zinc carbonate, and 91.8 mg PLG.

Each 22.5 mg 3 cc single-use vial of Nutropin Depot (somatropin rdna origin for inj) contains 22.5 mg somatropin, 2.0 mg zinc acetate, 1.4 mg zinc carbonate, and 114.8 mg PLG.

Each dosage size contains an overage of rhGH microspheres to ensure delivery of labeled contents.

Each 1.5 mL single-use vial of Diluent for Nutropin Depot (somatropin rdna origin for inj) contains 30 mg/mL carboxymethylcellulose sodium salt, 1 mg/mL polysorbate 20, 9 mg/mL sodium chloride, and sterile water for injection; pH 5.8-7.2.

Nutropin Depot® [somatropin (rDNA origin) for injectable suspension] is indicated for the long-term treatment of growth failure due to a lack of adequate endogenous GH secretion.

Considerations for use: – As with any GH treatment, patients should be monitored closely throughout therapy for growth response to Nutropin Depot (somatropin (rdna origin) for inj) . Failure to respond adequately requires careful assessment, as described under DOSAGE AND ADMINISTRATION. Patients for whom no discernible cause is found should be considered for a course of treatment with a daily form of rhGH. Experience in patients who were treated with daily GH and switched to Nutropin Depot is limited.

DOSAGE AND ADMINISTRATION

The Nutropin Depot (somatropin (rdna origin) for inj) dosage and administration schedule should be individualized for each patient. Response to GH therapy in pediatric patients tends to decrease over time. However in pediatric patients, failure to increase growth rate, particularly during the first year of therapy, suggests the need for close assessment of compliance and evaluation of other causes of growth failure, such as hypothyroidism, undernutrition, and advanced bone age.

Once-Monthly Injection – It is recommended that an SC injection at a dosage of 1.5 mg/kg body weight be administered on the same day of each month. Dosages above the recommended once-monthly regimen have not been studied in clinical trials. Note: subjects over 15 kg will require more than one injection per dose.

Twice-Monthly Injections – It is recommended that an SC injection at a dosage of 0.75 mg/kg body weight be administered twice each month on the same days of each month (e.g., Days 1 and 15 of each month). Dosages above the recommended twice-monthly regimen have not been studied in clinical trials. Note: subjects over 30 kg will require more than one injection per dose.

The table below indicates the required number of injections per dose.

size chest(in.) waist(in.) hips(in.)
XS 34-36 27-29 34.5-36.5
S 36-38 29-31 36.5-38.5
M 38-40 31-33 38.5-40.5
L 40-42 33-36 40.5-43.5
XL 42-45 36-40 43.5-47.5
XXL 45-48 40-44 47.5-51.5

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